Gene information
Official symbol PROC
Official full name protein C, inactivator of coagulation factors Va and VIIIa
Gene type protein-coding gene
Chromosome2q14.3
Gene familyReceptor ligands; Gla domain containing
Resources
Entrez Gene 5624
HGNC HGNC:9451
Ensembl ENSG00000115718
Vega OTTHUMG00000131528
UCSC uc002tok.4
GO terms: 33 records
GO Description Category LogP Number of genes Detail
GO:0004175 endopeptidase activity GO Molecular Functions -25.2809598 44 More
GO:0004252 serine-type endopeptidase activity GO Molecular Functions -24.0834770 30 More
GO:0005509 calcium ion binding GO Molecular Functions -14.7764642 80 More
GO:0005788 endoplasmic reticulum lumen GO Cellular Components -47.2996164 57 More
GO:0005796 Golgi lumen GO Cellular Components -14.6918478 18 More
GO:0007596 blood coagulation GO Biological Processes -44.7281461 45 More
GO:0007599 hemostasis GO Biological Processes -44.1075001 45 More
GO:0008233 peptidase activity GO Molecular Functions -21.0463733 46 More
GO:0008236 serine-type peptidase activity GO Molecular Functions -23.9716175 31 More
GO:0009611 response to wounding GO Biological Processes -63.1714102 77 More
GO:0010720 positive regulation of cell development GO Biological Processes -17.713649 52 More
GO:0017171 serine hydrolase activity GO Molecular Functions -24.8900503 32 More
GO:0030193 regulation of blood coagulation GO Biological Processes -37.6853179 30 More
GO:0030195 negative regulation of blood coagulation GO Biological Processes -29.1940441 22 More
GO:0030856 regulation of epithelial cell differentiation GO Biological Processes -15.4645914 35 More
GO:0031347 regulation of defense response GO Biological Processes -64.5971043 148 More
GO:0031348 negative regulation of defense response GO Biological Processes -30.3795513 65 More
GO:0032102 negative regulation of response to external stimulus GO Biological Processes -54.2675416 110 More
GO:0042060 wound healing GO Biological Processes -56.2139708 65 More
GO:0045601 regulation of endothelial cell differentiation GO Biological Processes -11.5275821 17 More
GO:0050727 regulation of inflammatory response GO Biological Processes -68.5964592 121 More
GO:0050728 negative regulation of inflammatory response GO Biological Processes -31.0556128 55 More
GO:0050817 coagulation GO Biological Processes -44.4773041 45 More
GO:0050818 regulation of coagulation GO Biological Processes -40.0839917 32 More
GO:0050819 negative regulation of coagulation GO Biological Processes -31.8350192 24 More
GO:0050878 regulation of body fluid levels GO Biological Processes -57.9546976 69 More
GO:0060284 regulation of cell development GO Biological Processes -22.9455891 78 More
GO:0061041 regulation of wound healing GO Biological Processes -35.8633788 36 More
GO:0061045 negative regulation of wound healing GO Biological Processes -28.2986689 25 More
GO:1900046 regulation of hemostasis GO Biological Processes -39.0044157 31 More
GO:1900047 negative regulation of hemostasis GO Biological Processes -30.8008788 23 More
GO:1903034 regulation of response to wounding GO Biological Processes -34.9293555 38 More
GO:1903035 negative regulation of response to wounding GO Biological Processes -27.3379640 26 More
KEGG pathways: 1 record
KEGG Description Category LogP Number of genes Detail
hsa04610 Complement and coagulation cascades KEGG Pathway -50.1154932 39 More
Drug-Gene interaction
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Related drugs: 8 records
Related studies: 7 records
Molecular factor Omics type Application Objective MI type Reference
vitamin K-dependent protein C proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Moyssakis I et al. Blood Coagul Fibrinolysis. 2010
vitamin K-dependent protein C proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Ben Romdhane N et al. Tunis Med. 2012
vitamin K-dependent protein C proteomics thromboembolism[prognosis (bad)] acute myocardial infarction Ben Romdhane N et al. Tunis Med. 2012
vitamin K-dependent protein C proteomics acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Tanalp AC et al. Coron Artery Dis. 2013
vitamin K-dependent protein C proteomics cardiogenic shock[prognosis (bad)] acute myocardial infarction Fellner B et al. Eur Heart J Acute Cardiovasc Care. 2017
vitamin K-dependent protein C proteomics death[prognosis (bad)] acute myocardial infarction Fellner B et al. Eur Heart J Acute Cardiovasc Care. 2017
vitamin K-dependent protein C proteomics no-reflow phenomenon[prognosis (bad)] acute ST elevation myocardial infarction Stankovic S et al. Acta Cardiol. 2019
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